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Footnotes and sources. Bone mass, bone geometry, and body composition in female-to-male transsexual persons after long-term cross-sex hormonal therapy. All aforementioned physical changes can, and reportedly do, change the experience of sensation compared to prior to HRT. Studies looking at the effects of estrogen on cardiovascular disease in transgender women are not very conclusive, but do show that there may be a trend toward an increased risk of heart disease, which should be further studied. Archived from the original on 3 June Sex steroids—testosterone and estradiol—are necessary to maintain bone health in men and women, respectively. As a result, there are strong recommendations against the use of ethinyl estradiol in transgender patients 8.

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Breast Cancer Epidemiology. Acta Clin Belg. Demegestone Promegestone Trimegestone Testosterone derivatives: J Sex Med.

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Retrieved 31 July

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